A Novel Method for Repairing Sensitive Skull and Facial Bone Injuries
An international team of researchers, led by specialists from the National Institute for Genetic and Biological Resources of Iran and Shahid Beheshti University, has introduced a groundbreaking method for repairing sensitive skull and facial bone injuries.
According to Mehr News Agency, citing the National Institute for Genetic and Biological Resources, affiliated with Jahad-e-Daneshgahi, the new therapeutic approach results from collaborations between reputable domestic and international academic centers. These include Shahid Beheshti University, the Pasteur Institute of Iran, Wenzhou Medical University in China, Yuan Ze University in Taiwan, Savitribai Phule Pune University in India, and Istinye University in Turkey. The project was spearheaded by Dr. Hossein Shahsavarani and Dr. Mehdi Jahangfar, offering an innovative solution for the repair of sensitive bone injuries in the skull and face.
In modern life, the increasing incidence of various injuries has made bone defect repair, especially in sensitive areas such as the skull, jaw, and face, one of the significant challenges in regenerative medicine. Research teams worldwide have been striving to develop more effective therapeutic solutions. Among these, stem cell technology and nanotechnology have garnered significant attention in recent years as key strategies.
The new therapeutic method presented in this research involves cultivating stem cells on a natural cellulose scaffold coated with silica nanoparticles and proanthocyanidin, a natural compound extracted from grape seeds. This scaffold not only facilitates the differentiation of stem cells into bone cells but also supports their growth and proliferation without requiring antibiotics.
Preclinical tests have shown that this scaffold enhances alkaline phosphatase enzymatic activity, mineralizes the bone matrix, and produces collagen, thereby accelerating and improving bone tissue regeneration. Furthermore, the antibacterial properties of this scaffold against both gram-positive and gram-negative bacteria reduce the risk of postoperative infections.
Additionally, preclinical studies revealed that the developed cellular scaffold significantly aids in vascular regeneration, reduces inflammation, and supports epithelial tissue repair. These features make this technology a comprehensive and effective solution for bone injury repair.
Inspired by nature and utilizing advanced nanotechnology and stem cell approaches, this innovative therapeutic method represents a major breakthrough in treating bone injuries. It also highlights the scientific capabilities of Iran on a global scale, despite numerous sanctions and limitations. Upon completing upcoming clinical phases, this technology is expected to be widely applied to treat skull and facial injuries in the near future.
