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190292
Wed, 06/22/2011 - 08:16
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OMICS AT THE WORLD CONGRESS OF DERMATOLOGY

By Rohana Mustaffa

This is the first of a three part series on Omics

KUALA LUMPUR, June 22 (Bernama) -- The 22nd World Congress of Dermatology
(WCD) was held in Seoul, Korea, recently. It brought together an international
audience of 12,000 people, most of them leading dermatologists, scientists,
health professionals and researchers from over 100 countries.

Since its launch in 1889 in Paris, the Congress, which is held every four
years, has strived to promote and improve skin health across the world.

At the Congress, experts in the fields of dermatology, beauty and grooming
shared knowledge, innovation and research breakthroughs in skin health.

“Almost everyone is affected by at least one skin disease at some stage in
their lives. As a population ages, dermatology practices also change to meet new
needs,” said the CEO of a company.

Dermatologists, he said, were taking a holistic approach to skin care. They
were not only treating wrinkles, but also other issues associated with aging,
such as pigmentation, facial-volume loss and body contouring. Dermatologists
were expecting that the technologies used in aesthetic treatments could also be
extended to other dermatological conditions.

BREAKTHROUGH

Procter & Gamble, a global leader in pharmaceuticals, beauty and grooming
products, was one of the companies that participated in WCD. At this year’s
meeting, its team demonstrated its leadership in science and innovation.

P&G unveiled its pioneering efforts in the field of ‘Omics’ -- a
comprehensive analysis of biological systems.

“Omics is a fun way of saying genomics, proteomics and metabolomics,” said
Mary Johnson, a P&G Principal Scientist, describing a field of genomics that
emerged 21 years after the Human Genome Project began in 1990.

The Omics revolution at P&G began with breakthroughs in genomics over 10
years ago.

“It’s like a birthday party," said Johnson, on the joint application of
genomics, proteomics and metabolomics to map the biological system. Omics tools
can also aid skin, nail and hair research.

THE THREE OMICS

Proteomics is the large-scale study of proteins, and tracks how genomic
activity affects proteins within the body. It is considered the next step in the
study of biological systems, after genomics.

Proteomics measures the presence and quantity of specific proteins, giving
researchers greater insight into how changes in the body can affect skin and
hair. Proteomics is often studied in conjunction with genomics.

Metabolomics, meanwhile, studies how changes in genes and proteins trigger
biochemical processes inside cells.

In beauty research by the P&G scientists, metabolomics tracks ingredients
that influence metabolites in skin and hair cells, and helps in developing new
ingredients and applications.

At this year's WCD, P&G brought international experts, including over 20
beauty and grooming scientists, to speak about Omics at the four symposiums
sponsored by the company.

“We explained the tools of Omics, and how it was applied in P&G grooming
programmes, at the symposium,” said Johnson.

“It is a huge investment, in terms of time and training. The latest Omics
tools now allow us to monitor 9.4 million gene changes, and hundreds
of protein expression changes, or metabolites, in a single experiment," she
added.


A HOT TOPIC

P&G said it was happy that Omics was an area of interest at the WCD,
considering a non–sponsored plenary lecture was also focused on Omics. The firm
believes Omics can be applied to areas other than dermatology.

A special lecture, titled ‘Whole Genome Sequencing Impact on Dermatology’,
was delivered by Professor Magnus Nordnorg, the science director at Grego Mendel
Institute of Austria, at the WCD.

He discussed the prospects and limitations of genome-wide association
studies (GWAS) in the era of whole-genome sequencing. According to him, Omics
studies are characterised by large amounts of data that require bio-informatics
- computer-based analytics which draw on large databases and analysis tools
across diverse disciplines.

Dr Jay Tiesman, principal scientist at the Global Biotechnology Division of
P&G, said the Omics revolution has significantly changed how scientists perceive
and analyse beauty and grooming.

“It has changed the rules of the game, and given us an unrivalled insight
into the complete map of our biological processes. It will help us solve the
molecular puzzles of beauty and grooming science,” said Dr Tiesman.

-- BERNAMA




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